TNFAIP2 and esophageal squamous cell carcinoma: In recent years, studies have found that SNPs in mRNA 3′ UTR may impact the miRNA-mediated expression and regulation of oncogenes and tumor suppressors and confirmed that TNFAIP2 3′ UTR SNPs are correlated with risk of multiple malignancies, especially that TNFAIP2 3′ UTR rs8126 polymorphism may affect TNFAIP2 expression in GC, SCCHN, and ESCC by disturbing the binding of miR-184 with TNFAIP2 mRNA (14, 18, 19).