Recently, some studies have confirmed the relationship between TNFAIP2 SNPs and malignant tumors such as head and neck squamous cell carcinoma (SCCHN) and esophageal squamous cell carcinoma (ESCC), which is beneficial for screening high-risk groups and predicting outcomes of tumors (14, 15, 18, 19). This evidence concerns the gene TNFAIP2 and head and neck squamous cell carcinoma.