In melanoma, multiple signaling pathways are dysregulated, involving oncogenes and tumor suppressors (i.e., PI3K/AKT/mTOR, MAPK, RAS/MEK/ERK, BRAF, and CDK); the multiple dysregulation of these signaling pathways favors tumor invasiveness, progression, drug resistance, and recurrence. The gene discussed is AKT1; the disease is neoplasm.