SRSF6 and breast carcinoma: As shown in Figure 5, the identified PBMC biomarkers (TMSB4X, HSPA4, S100A9, SRSF6, THBS1, CUL4A, and CANX) were significantly upregulated in the breast cancer patients at the metastatic stage compared to both the primary stage and healthy individuals (p < 0.001).