The results showed that the levels of autoantibodies against ALDH1B1 were higher in samples from CRC and AA patients, especially AA, compared with those from healthy controls (Figure 6), which was consistent with the ELISA results, in which the AUC values to discriminate AA and CRC were 0.75 and 0.70, respectively. The gene discussed is ALDH1B1; the disease is colorectal carcinoma.