For autoantibodies screened by SERPA, the results showed that autoantibodies against ALDH1B1 and UQCR1 may have underlying value for CRC patients with AUC values of 0.62 and 0.64, sensitivities of 37.60 and 47.20%, and specificities of 84.68 and 64.86%, respectively. The gene discussed is ALDH1B1; the disease is colorectal carcinoma.