For example, the definition of PD-L1+GC/GEJC is based on a comprehensive positive score, including the expression on tumor cells, lymphocytes, and macrophages, which is different from the definition in lung cancer (25); there is still no consensus on the cutoff value of PD-L1-positive expression, and the expression of PD-L1 was affected by many factors such as standardization of measurement methods, antitumor therapy, and immune response of the host. This evidence concerns the gene CD274 and neoplasm.