Considering the limited progress of traditional therapy, like chemotherapy and anti-Human epidermal growth factor receptor-2 (HER-2) therapy in improving the generally disappointing outcomes (2), and the genetic complexity and heterogeneity of GC/GEJC, immunotherapies have gradually been developed and advanced into novel frontiers of treatment for advanced GC/GEJC, entirely revolutionizing the therapeutic landscape in the last 10 years. Here, ERBB2 is linked to gastric cancer.