DU-145 was selected for in-depth investigations for the following reasons: (a) fast induction of cell death by (2)Ga in this cell line; (b) its relatively high metastatic potential18,19; (c) elevated levels of SPARC expression, the protein responsible for increased albumin uptake in metastatic prostate cancer cells44,45; and (d) its potential role as a preclinical in vitro model for mCRPC46. The gene discussed is SPARC; the disease is Familial prostate cancer.