Multiple studies have dissected that FBXO22 could regulate the expression of several downstream targets, such as hypoxia-inducible factor (HIF1α), vascular endothelial growth factor A (VEGFA), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and metalloproteinase-9 (MMP-9) in human cancer cells49,50. The gene discussed is FBXO22; the disease is cancer.