Eleven of the 14 SNPs were significantly associated with an increased risk of FH, including 1 SNP in LDLR, 7 in APOB, and 3 in PCSK9. The study showed that APOB rs12720762 was associated with the highest risk of FH (odds ratio 14.78, p < 0.001) (Lye et al., 2013). This evidence concerns the gene APOB and familial hyperaldosteronism.