LDLR and familial hyperaldosteronism: To study the role of the LDLR gene in polygenic hypercholesterolemia, a study was conducted in 244 members of 43 different pedigrees (15 normal and 28 FH pedigrees) and 245 individuals (187 normal and 58 FH) for 9 different restriction fragment length polymorphisms (RFLPs) (TaqI, StuI, HincII, BstEII, AvaII, PvuII, MspIA, MspIB, and NcoI) and a sequence variation at Arg450.