IGF2R and cervical carcinoma: Xia et al. (2019) investigated canolol induced apoptosis in Hela cells via the mitochondrial signaling pathway. Takeda et al. (2019) found that insulin like growth factor 2 receptor (IGF2R) disorders could cause lysosome dysfunction and regulate the apoptosis of cervical cancer cells. Furthermore, mitochondria and lysosomes interact with each other during cellular activity and regulate apoptosis. Wong et al. also reported the functional correlation between mitochondrial and lysosomal dysfunction (Wong Y. C. et al., 2018b).