PTPN6 and cancer: From this IRG–TF regulatory network, we can see that in cervical cancer, STAT1 positively regulates low-risk IRGs (PSME2, LTA, and PTPN6), but STAT1 positively regulates high-risk IRGs (OAS1) in endometrial cancer, suggesting that transcription factor STAT1 may play different biological roles in these two types of cancers.