TOPORS and early-onset autosomal dominant Alzheimer disease: By searching in the InnateDB database, several candidate genes associated with the immune system were found in S. caldwelli, including POLR3B, PIK3C3, TOPORS, FASTKD3, CYP1A1, and UACA. POLR3B is an antiviral molecule, which has been reported capable of confusing purine metabolism and has something to do with Alzheimer’s disease (Ansoleaga et al., 2015).