These significant associations imply that an imbalance between CD226 and TIGIT exists in the CD8+ T cells of PBC patients, which could lead to liver damage when the proportion of CD226+ cells among the CD8+T cells is higher than that of TIGIT+ cells among the CD8+T cells, presenting as elevated digestive enzyme levels in serum and decreased ability of synthesizing liver proteins such as albumin. The gene discussed is ALB; the disease is primary biliary cholangitis.