Significantly increased frequency of CD8+CD226+T cells was found in PBC patients compared to that in the DCs (71.81 ± 11.99 vs. 55.67 ± 13.66, p < 0.001) and HCs (71.81 ± 11.99 vs. 52.04 ± 14.12, p < 0.001) (Figure 1A). This evidence concerns the gene CD8A and primary biliary cholangitis.