Experimental autoimmune neuritis (EAN) is a well-accepted animal model mimicking acute inflammatory demyelinating polyneuropathy (AIDP), which represents the major subtype of GBS, and studies from EAN and human pathological data have illuminated the immune rationale underlying AIDP, in which CD4+ T cells and macrophages play dominant roles (2). This evidence concerns the gene CD4 and Guillain-Barre syndrome, familial.