Even if few studies exist on the predictive role of myeloid subsets, Capone et al. observed that BRAF WT melanoma patients with durable clinical benefit from Ipilimumab had a reduced transcriptomic “myeloid score.” In the same cohort, the downregulation of CD73 gene, expressed by tumor-infiltrating myeloid cells as previously discussed, was also associated with response, irrespective of the BRAF status (128). This evidence concerns the gene NT5E and neoplasm.