However, when the myeloid compartment of the same cohort was analyzed in detail by single-cell RNA sequencing (scRNAseq), TAMs of responders were found to express CXCL10 and CXCL11 which, together with CXCL9, are predictive markers of response to anti-PD-1 and anti-PD-L1 in metastatic melanoma and mUC. Here, PDCD1 is linked to metastatic melanoma.