This short review describes how Eμ and 3'RR enhancers might play a critical role in c-myc deregulation during c-myc-induced mature B-cell lymphomas, why these models are not silver bullets to totally mimic human B-cell lymphomagenesis and why it is possible that targeting the 3'RR would be an interesting strategy in human B-cell lymphomagenesis. Here, MYC is linked to B-cell non-Hodgkin lymphoma.