The KI of c-myc in the mouse IgH locus just 5′ to Eμ (namely iMycEμ mice), thus modeling human endemic BL, induced, as expected, B-cell lymphoma development with alterations in the p19Arf-Mdm2-p53 tumor suppressor axis (66) and NF?B/STAT3/PI3K signaling (67). This evidence concerns the gene TP53 and B-cell non-Hodgkin lymphoma.