MYC and B-cell non-Hodgkin lymphoma: The same comments can be made for the transgenic mouse model of Wang and Boxer (59) which develops mature B-cell lymphomas (CD19+B220+IgM+IgDlow) after the KI of a 3'RR cassette upstream of the endogenous c-myc gene (this model is the reverse of natural c-myc translocation into the human IgH locus) (Figure 2).