c-myc KI in the mouse IgH locus just 5′ to Cμ with Eμ deletion (namely iMycCμ mice), thus modeling human sporadic BL, confirmed that 3'RR alone is sufficient to deregulate c-myc in the B-cell lineage and to induce B-cell lymphoma development (70). This evidence concerns the gene MYC and Burkitt lymphoma.