The inhibition of these key enzymes may have important biological consequences, such as: (i) inhibition of C-mediated lysis, (ii) a decrease in the C3a and C5a (anaphylotoxins) generation (these small C fragments are essential in the recruitment of blood cells to the infection site), and (iii) a decreased opsonization, which mediates phagocytosis of pathogens during infection (25). The gene discussed is C5; the disease is infection.