CFP and Sepsis: While lack of properdin often protects host from exacerbated inflammation, lack of properdin in mice can be deleterious in other disease models such as colitis (51, 52), Listeria monocytogenes-induced septicemia (46), polymicrobial septic peritonitis (53), LPS-induced non-septic shock (49), and C3 glomerulopathy where Factor H is also absent in the mice (54, 55).