Hoechst and colleagues have shown that CD14+HLA-DR−/low M-MDSCs from hepatocellular carcinoma patients induce suppressive CD4+CD25+Foxp3+ Tregs in a contact-dependent manner when co-cultured with autologous CD3/CD28-stimulated CD4+ T cells (57). The gene discussed is CD4; the disease is hepatocellular carcinoma.