FFAR2 and graft versus host disease: In a murine model of GVHD, mice orally force-fed with GPR43 antagonist GLPG0974 (10 mg/kg/day) demonstrated significant higher GVHD than control, indicating a protective effect against GVHD when butyrate can bind FFA2/GPR43 (Fujiwara et al., 2018).