In particular, at the start of the GWAS era, we showed in 132 patients with severe hypertriglyceridemia and 351 controls that genotypes for common variants in APOA5, APOE, GCKR, TRIB1, and MLXIPL were significantly associated with severe hypertriglyceridemia in multivariate regression analyses and that these variants collectively explained about one-quarter of the variation in disease status (60). The gene discussed is APOE; the disease is hypertriglyceridemia.