APOA5 and hypertriglyceridemia: Most recently, in 563 patients with severe hypertriglyceridemia whom we analyzed with LipidSeq, we found that 14.4% had heterozygous rare variants in LPL, APOC2, GPIHBP1, APOA5, and LMF1 genes, compared to only 3.8% of normolipidemic controls, giving an odds ratio of 4.41 (95% confidence interval [CI]) 2.67–7.29, P < 0.0001) (16).