In 2012, we found an excessive prevalence of rare variants in LPL, APOC2, GPIHBP1, APOA5, and LMF1 in patients with severe hypertriglyceridemia (45), again indicating that heterozygosity was a predisposing factor for, although not an absolute cause of severe hypertriglyceridemia or MCM. This evidence concerns the gene APOC2 and hypertriglyceridemia.