CHL1 and Parkinson disease: Other potential mediators include regulated on activation, normal T expressed and secreted (RANTES), a chemokine correlated with motor involvement in PD patients (23); cathepsin D, a protease whose activity has been related to cell death in primate models of PD (24); myeloperoxidase (MPO), an enzyme with neurotoxic effects in a rodent model of PD (25); neural cell-adhesion molecule (NCAM) (26), a potential neurotrophic mediator; and platelet-derived growth factor isotype BB (PDGF-BB), whose regenerative properties have been demonstrated in a rat model of PD (27).