We also found that FoxO1 rs17592371 and rs28553411, A2M rs10842847, rs10842849, and rs226415, and TGF-β1 rs12462166 and rs12983775 interacted with the environment in MDD, suggesting a potential relationship between these genes and the etiology of MDD, which could be a bona fide association or the result of linkage. This evidence concerns the gene TGFB1 and major depressive disorder.