PPARGC1A and early-onset autosomal dominant Alzheimer disease: Recent studies have shown that activation of the SIRT1/PGC-1α signaling pathway can promote the expression of antioxidant enzymes and improve free radicals associated disorders (Wang S.J. et al., 2015; Bu et al., 2017) such as Alzheimer disease and type 2 diabetes (Satoh et al., 2013; Herskovits and Guarente, 2014).