Contrary to these deleterious effects, activation of P2X7 by the potent agonist 2′(3′)‐O‐(4‐benzoylbenzoyl) adenosine 5′‐triphosphate in SOD1-G93A mice (for seven days just before the onset of pathological neuromuscular features) improves morphology of neuromuscular junctions, metabolism of myofibers, proliferation/differentiation of satellite cells, overall ameliorating denervation atrophy in ALS skeletal muscles (Fabbrizio et al., 2020). The gene discussed is P2RX7; the disease is amyotrophic lateral sclerosis.