P2RX7 and amyotrophic lateral sclerosis: By building upon some recent success and exciting new pharmacological developments about P2X7 (De Marchi et al., 2016; Rech et al., 2016; Park and Kim, 2017; Pevarello et al., 2017; Górecki, 2019), here we discuss the reasons and the key challenges of fostering research in the field of P2X7 and ALS.