SQSTM1 and amyotrophic lateral sclerosis: In the ALS context, we know that a short P2X7 activation sustains a positive flux of autophagy by upregulating LC3B-II protein via the mTOR pathway and downregulating SQSTM1/p62 levels in SOD1-G93A primary microglia, concurrently with induction of M2 anti-inflammatory markers.