Indeed, we found that 11H-indeno[1,2-b]quinoxalin-11-one oxime salt (IQ-1S) was an effective JNK inhibitor that blocked proinflammatory cytokine production and that IQ-1S treatment had a beneficial therapeutic effect in a mouse model of RA (Schepetkin et al., 2012; Schepetkin et al., 2015). The gene discussed is MAPK8; the disease is rheumatoid arthritis.