MAPK8 and Arthritis: Although the differences in therapeutic effects of TRYP and TRYP-Ox were not significant, the therapeutic effects of TRYP and TRYP-Ox were significantly greater at days 6 and 7 compared to mice treated with IQ-1S, a JNK inhibitor that we previously showed to inhibit arthritis in the CIA model (Schepetkin et al., 2015).