The miRNA-34 loaded NPs repressed the expression of oncogenic CD44 protein with decreased levels of Bcl-2, Oct-3/4 and Nanog genes, thus leading the suppression of CSCs-like characteristics, induction of apoptosis, reduction of cell invasion and metastasis and tumor growth inhibition in xenograft gastric cancer models (Jang et al., 2016; Fan et al., 2017). Here, CD44 is linked to neoplasm.