In addition to its biocompatibility and biodegradability, HA backbone possesses tumor-targeting properties through specific binding to CD44, an integral membrane glycoprotein overexpressed on the surface of various tumor cells (Aruffo et al., 1990) that makes it as an ideal polymer carrier for systemic drug delivery applications (De La Fuente et al., 2008). The gene discussed is CD44; the disease is neoplasm.