In a prospective study, genetic analysis revealed significant differences between the PDE4D (rs1588265) gene in patients with no history of nasal polyposis (a type of AR) and patients with nasal polyposis, indicating the potential of using a PD4 inhibitor for the management of patients with nasal polyposis (Apuhan et al., 2013). Here, PDE4D is linked to Nasal polyposis.