Although we reviewed several studies here, there are many unanswered questions that require further investigation: (i) Is it possible to make nNav1.5 a biomarker of early diagnosis of breast cancer; (ii) Can we develop additional agents specifically blocking INaP or nNav1.5 to improve efficacy and reduce side effects; and (iii) How can we accumulate the process of translational medicine and promote the application of these agents in the clinic to improve the outcomes for breast cancer patients. This evidence concerns the gene NFKBIZ and breast carcinoma.