Dioscin increased apoptosis in PCa cells by promoting the expression of phosphorylated SHP1-p-SHP1 (Y536), inhibiting the expression of p-Erk1/2 (T202/T204), p-P38 (T182) and p-P38(T180) and promoting the expression of apoptosis-related proteins caspase-3 (17/19KD) and Bad. Here, MAPK3 is linked to posterior cortical atrophy.