In addition, the MAPK signaling pathway is closely related to cancer progression (Wagner and Nebreda, 2009; Cuadrado and Nebreda, 2010) and activation of caspase-3 or Bad promotes cell apoptosis (Gajewski and Thompson, 1996; Porter and Janicke, 1999; Min et al., 2004). Here, CASP3 is linked to cancer.