CNR1 and central nervous system cancer: On the other side, the effect of both the selective (ACEA) and non-selective (WIN55,212-2) CB1R agonist on tau hyper-phosphorylation was selectively induced by the CB1R in Aβ-induced C6 glioma cells co-cultured with PC12 neuronal cells through down-regulating inducible nitric oxide synthase (iNOS) and nitric oxide (NO) generation (Esposito et al., 2006b).