Therefore, fatty acid amide hydrolase (FAAH), the endocannabinoid metabolizing enzyme, is up-regulated in AD brains both in peripheral blood mononuclear cells (D’Addario et al., 2012) and neuritic plaque-related glia (Benito et al., 2003), and this can lead to the increase of the degradation of AEA in the surrounding area of the senile plaque. Here, FAAH is linked to Alzheimer disease.