Neuropathological hallmarks of AD are extracellular accumulations of amyloid beta (Aβ) as well as intracellular accumulations of neurofibrillary tangles (NFTs) that are comprised of hyperphosphorylation of tau (Uddin et al., 2019; Mamun et al., 2020; Uddin et al., 2020d). The gene discussed is MAPT; the disease is Alzheimer disease.