CNR1 and Senile plaques: Although, some studies found that a considerable decrease in the levels of CB1R in cortical areas as well as in neurons faraway from senile plaques (Ramírez et al., 2005; Solas et al., 2013), however, many investigations have reported no changes in the distribution and expression of CB1R in hippocampus and cortex in AD (Benito et al., 2003; Ahmad et al., 2014; Lee et al., 2010; Mulder et al., 2011).