The signaling network defined by phosphoinositide 3-kinase (PI3K), AKT, and mammalian target of rapamycin (mTOR) controls most hallmarks of cancer, including cell cycle progression, survival, metabolism, motility, and genomic instability (Engelman, 2009; Pal and Mandal, 2012; Fruman and Rommel, 2014). The gene discussed is AKT1; the disease is cancer.