HMOX1 and Hyperglycemia: The results showed that hyperglycemia induced the upregulation of caspase-3 and caspase-9 (F = 23.95, p < 0.05; Figure 6A; F = 19.37, p < 0.05; Figure 6B), downregulation of Nrf2 and HO-1 (F = 21.58, p < 0.05; Figure 6C; F = 23.72, p < 0.05; Figure 6D).