The results showed that SL downregulated the mRNA levels of IL-6 in the rats with diabetes (F = 13.18, p < 0.05; Figure 5E) and up-regulated the mRNA levels of IL-4 and IL-10 (F = 9.98, P < 0.05, F = 10.75, P < 0.05; Figures 5G,H); however, there were no significant differences in the mRNA levels of TNF-α between the four groups (F = 1.32, P > 0.05; Figure 5F). This evidence concerns the gene IL6 and diabetes mellitus.