By analyzing the two CMA regulators (LAMP2A and HSC70) in peripheral blood mononuclear cells (PBMCs) of ALS patients, it was found that the levels of the lysosome receptor LAMP2A were similar in control and ALS PBMCs, while the expression of the cytosolic chaperone HSC70 was found reduced, but the total amount of insoluble TDP-43 protein was found increased and accompanied by aberrant intracellular localization (Arosio et al., 2020). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.