Other authors have shown that LAMP2A downregulation induces the intracellular accumulation of the ALS-associated TDP-43 fragments of 35 and 25 kDa (Huang et al., 2014), and TDP-43 can also be forced to be degraded via CMA (Tamaki et al., 2018). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.