A recent study performed by the group of de Belleroche suggests that at least 40 different target genes, associated with ERAD and regulated by XBP1 or ATF6, are altered in spinal cord specimens from ALS patients; this is paralleled by severe alterations and activation of the IRE1α-XBP1 and ATF6 pathways (Montibeller and de Belleroche, 2018). The gene discussed is ERN1; the disease is amyotrophic lateral sclerosis.