Other mutant genes are less frequently represented in fALS: examples are the genes encoding TAR DNA-binding protein 43 (TDP-43), the ALS-linked fused in sarcoma/translocated in liposarcoma (FUS/TLS), the ubiquilin-2, the optineurin, the valosin-containing protein/p97 (VCP/p97), and others. The gene discussed is TARDBP; the disease is sarcoma.