Alzheimer’s disease is also associated with CMA since the beta-amyloid peptide (Aβ), the microtubule-associated protein Tau or the Regulator of calcineurin 1 (RCAN1) are involved in Alzheimer’s disease and are dysregulated when CMA is altered (Liu et al., 2009; Wang et al., 2009, 2010; Park et al., 2016). Here, RCAN1 is linked to early-onset autosomal dominant Alzheimer disease.