ADARB1 and amyotrophic lateral sclerosis: Downregulation of ADAR2 and subsequent increases in CP-AMPARs has been identified as a key step in the progression of motor neuron loss in ALS (Kwak and Kawahara, 2005; Hideyama et al., 2012; Lorenzini et al., 2018; Yamashita and Kwak, 2019).