Conversely, in an AD mouse model, inhibitors of NLRP3 or caspase-1 have been shown to significantly enhance the ability of microglia to clear Aβ deposits, reduce Aβ deposition, and improve cognitive impairment and hyperactive behavior (Heneka et al., 2013; Dempsey et al., 2017). The gene discussed is CASP1; the disease is Alzheimer disease.