NLRP3 and Parkinson disease: Inhibiting the downstream pathway of the NLRP3/caspase-1/IL-1β axis using Ac-YVAD-CMK, a caspase-1 inhibitor, improves the number of DA neurons in the SN and alleviates symptoms in both LPS- and 6-OHDA-induced PD rats (Mao et al., 2017).