Our previous studies demonstrated that HPV-16 E7 oncoprotein up-regulated the expression of EMT-related markers including N-cadherin, Vimentin, ZEB1, and Snail1 and down-regulated the expression of E-cadherin and ZO-1 in A549 and NCI-H460 NSCLC cells 12. The gene discussed is CDH2; the disease is non-small cell lung carcinoma.