In the present study, we further found that HPV-16 E7-induced HIF-1α protein accumulation and HIF-1α-dependent VEGF expression were inhibited by MAOA knockout, and MAOA knockout enhanced the degradation of HPV-16 E7-induced HIF-1α protein possibly via 26S proteasome pathway in NSCLC cells (Figure 4A-D). The gene discussed is VEGFA; the disease is non-small cell lung carcinoma.