In Paget's disease of bone, p62/SQSTM1 is a key regulator of ubiquitinated protein turnover through autophagy and ubiquitin-proteasome system, as well as positively stimulating NF-κB signaling and the oxidative stress-induced Kelch-like ECH-associated protein 1/NF-E2-related factor 2 (Keap1/Nrf2) pathway 98. The gene discussed is SQSTM1; the disease is bone Paget disease.