TNF and rheumatoid arthritis: Liu et al. 150 found in the mice with collagen-induced arthritis, polypeptide composite selenium nanoparticles induced vascular endothelial cells to produce NO (nitric oxide), NO induced AMPK-α phosphorylation, which could inhibit mTOR phosphorylation, increase autophagy flux, inhibit NF-κB-p65 phosphorylation and reduce the level of inflammatory cytokines (IL-1β, IL-6 and TNF-α) in the polypeptide composite selenium nanoparticles treated mice RA immune cells.