AKT1 and osteoporosis: Yang et al. 49 used dexamethasone to treat rats with induced osteoporosis, and found that resveratrol further promoted SIRT1 (Sirtuin1)-induced mitophagy activation by suppressing phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway.