JAG2 and breast cancer: The results demonstrated that the protein expressions of Notch and Notch ligand Jagged2, the key signaling pathway of BC growth, proliferation and metastasis, were significantly reduced in BC + Mel (i.e., group 2) than in BC (i.e., group 1), and were even more significantly reduced in BC + KDNotch/JAG2 (i.e., group 3) (Figure 8).