By the way, the content of miR-27b-3p was proved to be limited in drug-resistant tumor cells, while it has been proved that the up-regulation of miR-27b-3p can inhibit the expression of CYP3A4 and change the drug resistance of LS-180 cells—a kind of colon carcinoma cell line 176. The gene discussed is CYP3A4; the disease is neoplasm.