In the HCC sample, the relation of H-CAFs density with E-cadherin or with p-STAT3 were further testified by IHC, as showed in Figure S1A and S1B, respectively, E-cadherin expression levels were higher in the H-CAFslow subgroup than in the H-CAFsmoderate/high subgroup. This evidence concerns the gene STAT3 and hepatocellular carcinoma.