In order to identify that the expression of TG2 in HCC cells is regulated by IL-6/IL6R/STAT3 axis, we added Tocilizumab to HCC cells and found that pSTAT3-S727 is down-regulated with the addition of Tocilizumab and TG2 expression levels were also down-regulated (Figure 6C). This evidence concerns the gene IL6R and hepatocellular carcinoma.