As shown in Figure 6A, the addition of human recombinant IL-6 to HCC induced an increase in TG2 expression, and the expression level of TG2 was consistent with the serine 727 phosphorylation level of STAT3 (pSTAT3-S727), whereas the addition of different doses of human recombinant HGF could not induce pSTAT3-S727 and TG2 expression. This evidence concerns the gene IL6 and hepatocellular carcinoma.