Conversely, Ephrin type-A receptor 2 (EPHA2), a transcriptional RAS/RAF target [52], which is overexpressed in several human cancers, including CRC [53, 54], was more strongly upregulated at the protein level when p53R172H was present (Supplementary Fig. S3d). The gene discussed is EPHA2; the disease is colorectal carcinoma.