We thus examined the amounts of phospho-CaMKII (Thr-286) (Fig. 4A) and oxidized CaMKII (ox-CaMKII) (Fig. 4B) in the atrium of BO mice, and found that they were significantly increased (CaMKII (Thr-286): Control (n = 12) vs. BO (n = 10): 1.0 ± 0.3 vs. 1.6 ± 0.5 A.U., P < 0.01 vs. Control; ox-CaMKII: Control (n = 6) vs. BO (n = 8): 1.0 ± 0.1 vs. 1.2 ± 0.2 A.U., P < 0.05 vs. Control). The gene discussed is CAMK2G; the disease is bronchiolitis obliterans syndrome.