Interestingly, cell cycle dysregulation was recently identified in single cell RNA-seq analysis of microglia from a mouse model of Alzheimer’s disease (AD), with some of the same genes identified in our study, including Top2a, Hells, Ccne1, Spc25, Cenpe, Anln, Rsad2, and Ifitm335. Here, TOP2A is linked to Alzheimer disease.