TOP2A and early-onset autosomal dominant Alzheimer disease: Interestingly, cell cycle dysregulation was recently identified in single cell RNA-seq analysis of microglia from a mouse model of Alzheimer’s disease (AD), with some of the same genes identified in our study, including Top2a, Hells, Ccne1, Spc25, Cenpe, Anln, Rsad2, and Ifitm335.