POLD1 and colorectal carcinoma: POLD1 c.1562G>A (p.Arg521Gln) had been previously identified by our group in a 48-year-old CRC patient.7POLD1 c.1573C>T (p.Arg525Trp) co-occurred with ATM c.7220C>A (p.Ser2407*; rs1555122149) in a woman affected with multiple tumors.