In the case of the CRC and the stomach carcinoma, the hypermutation detected was due to the presence of microsatellite instability (MSI) (MMR deficiency signatures’ contribution: 77%), and to the presence of BRCA2 p.Pro1088Leufs*16 (BRCA1/2 signature contribution [3]: 52%), respectively. Here, BRCA1 is linked to gastric carcinoma.