MSH2 and intestinal disorder: The variant had been previously reported in six families, including a melanoma patient,10 a patient with early-onset CRC,3 an individual with colonic polyps and family history of CRC,36 a 63-year-old CRC patient,35 a woman diagnosed with breast cancer at age 31,35 and two first-degree relatives, who also carried the MSH2 c.942+3A>T pathogenic variant, diagnosed with three synchronic CRCs at age 30 and one CRC at age 33 respectively.35