For HT29, irradiation alone significantly delayed tumour growth, with mice reaching endpoint 35 days post-treatment, compared with 40 days for mice receiving combination therapy, a significant but smaller prolongation (Fig. 7d Supplementary Fig. 5d). Administration of the anti-FGF2 blocking antibody also greatly delayed tumour growth of irradiated MC38 tumours in syngeneic, immunocompetent mice. The gene discussed is FGF2; the disease is neoplasm.