Secondly, we assessed the 14 proteins (APOL1, C7, COMP, CKM, CRTAC1, CTSH, EFEMP1, FBLN1, GSN, HSPG2, IGHG1, IGKC, SHBG, MYH2) that were significantly altered in ALS by Bioprofiling and STRING. The gene discussed is IGKC; the disease is amyotrophic lateral sclerosis.