Upregulated Ybx1-bound genes were enriched in functions related to neural crest differentiation, transcriptional regulation, cell cycle, dopaminergic neurogenesis, transcriptional misregulation in cancer, and Hox genes in hindbrain development (Supplementary Fig. S4d), suggesting that Ybx1 directly suppresses genes involved in these functional categories. The gene discussed is YBX1; the disease is cancer.