Our findings suggest a regulatory network in NP cells: FUS bound to GRB10 pre-mRNA to regulate circ-GRB10 synthesis, while circ-GRB10 acted as a molecular sponge for miR-328-5p, with suppressive effects on ERBB2 production and modulated IDD development; downregulation of ERBB2 decreased Erk1/2 phosphorylation and promoted the generation of miR-141-3p, which bound to the 3′UTR region of FUS to inhibit its expression, constituting a positive feedback loop promoting intervertebral disc degeneration. Here, GRB10 is linked to intervertebral disk degenerative disorder.