HRAS and skin disorder: The dermatitis score was significantly higher in Dfb-treated HrasG12S/+ mice than in any other group of mice (4% SDS-treated control Hras+/+ mice, Dfb-treated Hras+/+ mice, and 4% SDS-treated control HrasG12S/+ mice) on day 11 (Fig. 1c and Supplementary Table 1).