We first tested the effect of picryl chloride, which induce contact dermatitis, and imiquimod, which induce psoriasis on the skin of Hras+/+ and HrasG12S/+ mice (Supplementary Fig. 1b, c), but no difference in skin lesions was observed between them (Supplementary Fig. 1d). The gene discussed is HRAS; the disease is contact dermatitis.