To address the implications of Gsta4 over-expression in a model of autoimmune demyelination we induced experimental autoimmune encephalomyelitis (EAE) in DAWt and DAGsta4 rats by sub-cutaneous injection of recombinant myelin oligodendrocyte glycoprotein (MOG) in adjuvant. This evidence concerns the gene OMG and experimental autoimmune encephalomyelitis.